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| Disease found: | Asherman Syndrome |
| Current as of: | October 8, 2024 |
| Disease Overview: | Acquired disorder of the uterus involving the formation of scar tissue that bonds the walls of the uterus together, often following surgical interventions (such as D&C) or infections [more]. |
| Signs and Symptoms: | Symptoms vary with extent of adhesions; common symptoms include reduced or absent menses with increased cramping and pain during menstrual cycle. Uterine factor infertility and pregnancy loss are also common. [more]. |
| Diagnosis: | Hysteroscopy, when available, is the gold standard diagnostic tool, allowing a real-time view of adhesions and the ability to treat at the same time; when hysteroscopy is unavailable, hysterosalpingogram is a cost-effective alternative [more]. |
| Treatment: | For patients desiring future fertility, hysteroscopy-guided adhesiolysis is the standard of care; hysterectomy is also a first-line option if fertility is not desired [more]. |
| Clinical Management: | Prevention of re-adhesions may be recommended for more severe/symptomatic cases; research is ongoing regarding the best method. Current options include: intrauterine Foley catheter for 5-7 days post-adhesiolysis, placement of IUD or intrauterine balloon, and hyaluronic acid barrier [more]. It is unclear whether estrogen supplements prevent recurrence [more]. |
| Referral: | Asherman Syndrome is managed by OB/GYN providers with experience in hysteroscopy. Referral to Medical Genetics Department, if available. Initial virtual care is also available through organizations like TeleRare Health. |
| Clinical Trials: | Stem cell therapy is an area of interest for current research [more]. A handful of clinical trials are currently recruiting. |