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| Disease found: | DReSS Syndrome |
| Current as of: | October 8, 2024 |
| Disease Overview: | A rare disorder that can affect the skin, blood and any internal organs, most commonly the liver, kidney, lungs and heart. The cause of DReSS is multifactorial involving drug-exposure, genetic predisposition, viral reactivation and immune system responses. [more info] |
| Signs and Symptoms: | Most common are a flu-like prodrome of malaise, sore throat, fever and swollen lymph nodes. Followed by maculopapular or morbilliform, urticated papular rashes and full body redness with exfoliative erythroderma. [more info] |
| Diagnosis: | The RegiSCAR criteria (Kardaun et al. 2007) and The Japanese Consensus Group criteria (Shiohara et al. 2007). [more info] |
| Treatment: | Systemic steroids alongside identification and immediate withdrawal the culprit drug. [more info] |
| Clinical Management: | The causative drug needs to be avoided indefinitely. [more info] |
| Referral: | Aziz, Mariam MD and Ishmael, Faoud MD [more info]. Referral to Medical Genetics Department, if available. Initial virtual care is also available through organizations like TeleRare Health. |
| Clinical Trials: | 2 non-recruting [more info] |