Dermatomyositis

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Disease overview

Inflammatory myopathy leading to degeneration of muscle and skin

Common symptoms

Proximal muscle achesweaknessand atrophyheliotrope rashscaling and redness of the knuckleselbowsand kneesedema surrouding the eyes

WHEN TO SUSPECT

  • Recommendation 1

    Presence of characteristic skin rash, progressive weakness of proximal muscles, elevated CK, aldolase, AST, and LDH, and abnormal findings on EMG. Adults should be evaluated for an underlying malignancy

HOW TO TEST

  • Recommendation 1

    Presence of characteristic skin rash, progressive weakness of proximal muscles, elevated CK, aldolase, AST, and LDH, and abnormal findings on EMG. Adults should be evaluated for an underlying malignancy

TREATMENT

  • Recommendation 1

    Glucocorticoids first-line with repeat measures of CK to monitor effectiveness before prednisone taper

PRIMARY CARE

  • Recommendation 1

    Adults diagnosed should undergo malignancy evaluation including breast, gynecologic, and/or rectal examination. Screening may include routine blood testing, analysis of urine and stool, chest x-rays, mammograms in women. Sun avoidance, sunscreens, topical glucocorticoids, methotrexate, mycophenolate, or IVIG may also be recommended

FURTHER SUPPORT

  • Recommendation 1

    Rheumatology, immunology. Referral to Medical Genetics Department, if available. Initial virtual care is also available through organizations like TeleRare Health.

CLINICAL TRIALS

Sources

No data available

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