PRIMARY CARE
Recommendation 1
Early delivery with C-section may lower risk of ICH in a fetus with FNAIT. Newborns with FNAIT should receive a cranial ultrasound to assess for ICH. [more]
Fetal Alloimmune Thrombocytopenia
Not Verified
Disease overview
Maternal-fetal incompatibility leads to maternal antibodies forming against and attacking paternal antigens on fetal/neonatal platelets, resulting in platelet destruction and thrombocytopenia which can be severe [more].
Common symptoms
Severity variesbabies may be asymptomatichave skin purpura and petechiaeor sustain massive GI bleeds and intracranial hemorrhage [ ]. Severity of thrombocytopenia does NOT always correlate with risk of bleed.
WHEN TO SUSPECT
Recommendation 1
Commonly not diagnosed until symptoms are seen post-birth unless there is a known family history of FNAIT in older siblings. HPA genotyping of mother, father, and newborn and analysis of maternal blood for anti-HPA antibody presence can establish the diagnosis [more].
HOW TO TEST
Recommendation 1
Commonly not diagnosed until symptoms are seen post-birth unless there is a known family history of FNAIT in older siblings. HPA genotyping of mother, father, and newborn and analysis of maternal blood for anti-HPA antibody presence can establish the diagnosis [more].
TREATMENT
Recommendation 1
Symptomatic FNAIT in a newborn can be managed with platelet transfusion, ideally HPA-selected [more]Recommendation 2
most newborns will do well unless they sustain ICH. If there is family history of FNAIT in siblings, IVIG and steroids may be given to the pregnant mother beginning at 16 weeks’ gestation to reduce the risk of FNAIT occurring in the next child [more].
FURTHER SUPPORT
Recommendation 1
Families should be referred to maternal-fetal medicine and hematology specialists. AlloHope patient organization maintains a list of recommended maternal-fetal medicine specialists for FNAIT. Referral to Medical Genetics Department, if available. Initial virtual care is also available through organizations like TeleRare Health.
CLINICAL TRIALS
Recommendation 1
Two studies are currently recruiting, one in the USA and one in Europe.
Sources
No data available
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