Urticaria (Cold)

Not yet reviewed

This information is AI generated and has not yet been reviewed by a specialist physician. AI can make mistakes.

Disease overview

Chronic, reactive skin disorder in response to exposure to cold. Symptoms can last between 1 and 48 hours based on type. Familial type traced to chromosome 1q40. Other forms considered to be autoimmune disorders.

Common symptoms

Erythemahivesitching after exposure to cold temperatures. May be associated with feverheadacheanxietyfatiguepalpitationswheezingor syncope.

When to suspect

  • Recommendation 1

    Place an ice cube on the skin of the subject's forearm for 4-5 minutes. If hives occurs within 10 minutes of stimulus removal, patient likely has Cold Urticaria. In some cases, 20-30 minutes of exposure to cold air may cause the symptoms.

How to test

  • Recommendation 1

    Place an ice cube on the skin of the subject's forearm for 4-5 minutes. If hives occurs within 10 minutes of stimulus removal, patient likely has Cold Urticaria. In some cases, 20-30 minutes of exposure to cold air may cause the symptoms.

ZebraMD is partnering with Ambry Genetics for clinical-grade whole genome testing for rare diseases. Ambry accepts insurance. If you don’t have a physician to order this test, join our referral list and our team will reach out.

Treatment

  • Recommendation 1

    H1 receptor blockers and H2 receptor blockers (Tegamet) are effective. Can also use epinephrine, diphenhydramine, cyproheptadine, hydrochloride, and cetirizine.

Primary care

  • Recommendation 1

    Prevent symptoms with warm clothing, avoiding cold baths, swimming in cold water. Patient education, stimulus avoidance, and medications.

Further support

  • Recommendation 1

    Allergists and immunologists work with primary care providers to educate and manage patients.Referral to Medical Genetics Department, if available. Initial virtual care is also available through organizations like TeleRare Health.

Clinical trials

Clinical Trials

Sources

No data available

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